“DELTEX E3 ligases ubiquitylate ADP-ribosyl modifications on proteins and nucleic acids”

The speaker: Ivan Ahel is EP Abraham Professor of Chemical Pathology at the Sir William Dunn School of Pathology, University of Oxford. He earned his MSc in Molecular Biology from the University of Zagreb, Croatia, in 2000, and completed his PhD in Biology at Yale University, USA, from 2000 to 2003. His early research focused on the regulation of DNA damage response in actinomycetes and the mechanisms ensuring the fidelity of protein biosynthesis.

In 2004, Prof. Ahel joined Cancer Research UK at the London Research Institute (now part of the Francis Crick Institute) as a Post-doctoral Fellow in Stephen West’s group, where he investigated novel mammalian DNA repair factors. He began his first independent position in January 2009 at the Cancer Research UK Manchester Institute, before moving his laboratory to the University of Oxford in 2013.

Prof. Ahel's research has centered on understanding the roles of ADP-ribosylation signalling in DNA damage and immunity responses. He is a member of the European Molecular Biology Organization and a Fellow of the British Academy of Medical Sciences. His distinguished career is marked by significant contributions to the understanding of DNA repair and the molecular mechanisms underpinning cellular responses to DNA damage.

Teaser: In his presentation, Prof. Ahel will outline the dual, hybrid modification of macromolecules involving ADP-ribosylation and non-canonical ubiquitylation